A combination of active agents selected from a FoxM1 enhancer, an Id1 enhancer, and a JNK3 inhibitor and the uses thereof in promoting cardiomyocyte proliferation and treating heart diseases in a subject in need of the treatment.本揭示內容是關於一種選自FoxM1增強子、Id1增強子及JNK3抑制劑的活性藥劑組合物,以及該活性藥劑組合物於促進一有治療需要之個體之心肌細胞增生及治療一有治療需要之個體之心臟疾病的用途。