Byoung Joo GWAG,Young Ae Lee,Jin Hee Shin,Sung Ig Cho,Jae Sung Noh,Jae Young Cho,Ki Won Kim,Hyang Ran Lim,Jae Keun Lee,Han Yeol Byun,Sun Young Ko,Sun Joo Son,Sun Mi Park
申请号：
US13531366
公开号：
US20120301551A1
申请日:
2012.06.22
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to 2-hydroxy-alkylamino-benzoic acid derivatives and to a combination of cell necrosis inhibitor and lithium, process for the preparation of the derivatives or the combination, pharmaceutical formulation containing the derivatives or the combination, and use of the derivatives or the combination by either concomitant or sequential administration for improvement of treatment of neuronal death or neurological dysfunction. The derivatives and the combination of the present invention are useful for treating neurological diseases, such as amyotrophic lateral sclerosis (ALS, Lou Gehrigs disease), spinal muscular atrophy, Alzheimers disease, Parkinsons disease, Huntingtons disease, stroke, traumatic brain injury or spinal cord injury and for treating ocular diseases such as glaucoma, diabetic retinopathy or macular degeneration.
