A sterilizing cabinet assembly includes a cabinet (100; 2102; 2202; 2302; 2402; 2502; 2602) having a top, a bottom, sides, and an access port sized to pass a plurality of trays (1000), each tray (1000) sized to retain a plurality of instruments. The sterilizing cabinet assembly having a door (102; 606, 610; 2106; 2204; 2304; 2506; 2606) connected to the cabinet (100; 2102; 2202; 2302; 2402; 2502; 2602), the door (102; 606, 610; 2106; 2204; 2304; 2506; 2606) moveable between an open position permitting passage of the plurality of trays (1000) through the access port to an interior of the cabinet (100; 2102; 2202; 2302; 2402; 2502; 2602) and a closed position. The sterilizing cabinet assembly also comprises at least one of the cabinet top, sides and the door (102; 606, 610; 2106; 2204; 2304; 2506; 2606) having a vent (104) along a substantial portion of a surface of the cabinet top, sides, or door (102; 606, 610; 2106; 2204; 2304; 2506; 2606). The sterilizing cabinet further comprises a filter (108, 110; 1302; 1402; 1502; 1604; 1704, 1706; 1806; 1906, 1908; 2510) having a length and width corresponding to the size of vent (104), the filter (108, 110; 1302; 1402; 1502; 1604; 1704, 1706; 1806; 1906, 1908; 2510) overlying the vent (104) and forming a sealed interface with an adjacent portion of the one of the cabinet top, sides, and the door (102; 606, 610; 2106; 2204; 2304; 2506; 2606).