The invention relates to the combination of a sulforaphane precursor, an enzyme capable of converting the sulforaphane precursor to sulforaphane, an enzyme potentiator, and a mushroom (preferably maitake, shiitake, or reishi mushroom) extract or powder. The invention also relates to the combination of sulforaphane or a derivative thereof and a mushroom (preferably maitake, shiitake, or reishi mushroom) extract or powder. The present invention also relates to the combination of a broccoli extract or powder and a mushroom (preferably maitake, shiitake, or reishi mushroom) extract or powder. The present provides compositions and methods relating to these combinations.本發明係關於一種蘿蔔硫素前驅物、一種能夠將該蘿蔔硫素前驅物轉換成蘿蔔硫素之酵素、一種酵素增強劑,以及一種蕈菇(較佳者為舞菇、香菇或靈芝)萃取物或蕈菇粉末之組合。本發明亦與一種蘿蔔硫素或蘿蔔硫素之一種衍生物及一種蕈菇(較佳者為舞菇、香菇或靈芝)萃取物或蕈菇粉末之組合有關。本發明亦與一種青花菜萃取物或青花菜粉末及一種蕈菇(較佳者為舞菇、香菇或靈芝)萃取物或蕈菇粉末之組合有關。本發明提供與該些組合有關之組成物及方法。