THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY AND;MONASH UNIVERSITY;UNIVERSITY OF SOUTH AUSTRALIA;ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY
发明人:
Stavros SELEMIDIS,Doug A. BROOKS,John O'LEARY
申请号：
US16624367
公开号：
US20200216494A1
申请日:
2018.06.29
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates generally to the field of immunomodulation. Taught herein is an agent for inhibiting immunostimulation mediated by a Toll-like receptor useful in the treatment of viral and microbial pathogenesis, diseases involving elements of autoimmunity and inflammation as well as cancer. The agent antagonizes disulfide bond formation between C98 and C475 of Toll-like receptor 7 (TLR7) thereby preventing TLR7 activation. Pharmaceutical compositions are also enabled herein.
