Wo;Wo, Andrew Man Chung; Andrew Man Chung;Academia Sinica;National Taiwan University
发明人:
YANG, Pan-Chyr,LIN, Pei-Ying,HUANG, Bo-Tsang
申请号：
EP16789898
公开号：
EP3288963A4
申请日:
2016.05.02
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The present disclosure includes a PINK1-C-terminal domain (PINK1-CTD) polypeptide that binds to ERBB tyrosine kinase domain (ERBB-TKD) and therefore impedes ERBB from dimerization and activation. The PINK1-CTD polypeptide inhibits, prevents and/or treats ERBB-expressing cancers. The disclosure demonstrates the anti-tumor function of the PINK1-CTD, which provides a new direction for ERBB-expressing cancer therapy.
