The present invention relates to using a versatile synthetic approach togenerate a new class of ester, amido, or carbamate prodrugs of highly potent,but systemically too toxic platinum -acridine anticancer agents. The newhybrids contain a hydroxyl group which has been masked with a cleavablelipophilic acyl moiety. Both butanoic (butyric) and bulkier 2-propanepentanoic(valproic) esters were introduced to these compounds. The goal of this designwas to improve the drug-like properties of the pharmacophore (e.g., logD)without compromising its DNA-mediated cell kill potential. The compounds ofFormula l contain unique functional groups for the incorporation and deliveryof therapeutic components.(see formula I)
