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Apoptosis-inducing agents
专利权人:
AbbVie Inc.
发明人:
Tao, Zhi-Fu,Judd, Andrew S.,Souers, Andrew J.
申请号:
NZ72994413
公开号:
NZ729944A
申请日:
2013.08.12
申请国别(地区):
NZ
年份:
2018
代理人:
摘要:
Disclosed are compounds of formula (I) such as N-(1,3-benzothiazol-2-yl)-2-(4-{ [(4-{ [(2R)-4-(dimethylamino)-I-(phenylsulfanyl)butan-2-yl]amino} -3-nitrophenyl)sulfonyl]carbamoyl} -1,3-thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline-8-carboxamide which inhibit the activity of anti-apoptotic Bcl-xL proteins. Compositions containing these compounds are suitable for treating diseases during which is expressed anti apoptotic Bcl-xL protein, wherein the diseases includes bladder cancer, brain cancer, breast cancer, bone marrow cancer, cervical cancer, chronic lymphocytic leukemia, colorectal cancer, esophageal cancer, hepatocellular cancer, lymphoblastic leukemia, follicular lymphoma, a lymphoid malignancy ofT-cell or B-cell origin, melanoma, myelogenous leukemia, myeloma, oral cancer, ovarian cancer, non-small cell lung cancer, prostate cancer, small cell lung cancer and spleen cancer.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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