The present invention provides 9 subunit of pi for being bound to human IL-2 3 and using with high-affinity, selectivity and neutralize performance as the antibody of characteristic. The antibody can treat or prevent the autoimmunity or inflammatory conditions for being selected from multiple sclerosis, rheumatic arthritis, psoriasis, inflammatory bowel disease, ankylosing spondylitis, graft versus host disease, lupus and metabolic syndrome with what. What treating cancer also can be used in antibody.本發明提供了結合至人IL‑23的pi 9亞基並且以具有高親和性、 選擇性和中和性能爲特徵的抗體。所述抗體可用於治療或預防選自多發性硬化、風濕性關節炎、牛皮癬、炎症性腸道疾病、强直性脊椎炎、移植物抗宿主疾病、狼瘡和代謝綜合征的自身免疫或炎症狀况。抗體還可用於治療癌症。
