J. YUN TSO,KUI SHIN VOO,LAURA BOVER,NAOYA TSURUSHITA,SHANKAR KUMAR,YONG-JUN LIU
申请号：
BR112014003982
公开号：
BR112014003982A2
申请日:
2012.02.09
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
abstract human antibodies, preferably recombinant human antibodies, both humanized and chimeric, which specifically bind to human ox40 are disclosed. preferred antibodies have high affinity for ox40 receptor and activate the receptor in vitro and in vivo. the antibody may be a full-length antibody or an antigen-binding portion thereof. the antibodies, or antibody portions, are useful for modulating receptor activity, e.g., in a human subject suffering from a disorder in which ox40 activity is detrimental. nucleic acids, vectors and host cells for expressing the recombinant human antibodies are provided, and methods of synthesizing the recombinant human antibodies are also provided. patent summary for: "anti-ox40 antibodies and methods of using them". human antibodies, preferably both humanized and chimeric recombinant human antibodies that specifically bind to human ox40 are disclosed. Preferred antibodies have high affinity for the ox40 receptor and activate the receptor in vitro and in vivo. The antibody may be a full length antibody or antigen-binding portion thereof. Antibodies or antibody portions are useful for modulating receptor activity, for example, in a human subject suffering from a disorder in which ox40 activity is detrimental. Nucleic acids, vectors and host cells for the expression of recombinant human antibodies are provided and recombinant human antibody synthesis procedures are also provided.abstract human antibodies, preferably recombinant human antibodies, both humanized and chimeric, which specifically bind to human ox40 are disclosed. preferred antibodies have high affinity for ox40 receptor and activate the receptor in vitro and in vivo. the antibody can be a full-length antibody or an antigen-binding portion thereof. the antibodies, or antibody portions, are useful for modulating receptor activity, e.g., in a human subject suffering from a disorder in which ox40 activity is detrimental. nucleic acids, vectors and host cells for expressing th
