The present invention regards a composition in powder form for oral inhalation, preferably for oral aspiration, comprising a mucolytic agent, preferably N-acetylcysteine. Furthermore, the present invention regards said composition for use in a method for the treatment of a mucus hypersecretion and of diseases, symptoms or disorders associated with it in a needy subject. Lastly, the present invention regards a device for administration, through inhalation route by means of oral aspiration, to said needy subject.