KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
发明人:
KIM, Joon,KIM, Min Hwan,김민환
申请号：
KRKR2016/014543
公开号：
WO2017/164486A1
申请日:
2016.12.12
申请国别(地区):
WO
年份:
2017
代理人:
摘要：
The present invention relates to a composition for inhibiting resistance to anticancer agents, containing, as an active ingredient, a TESK1 inhibitor or an inhibitor for cofilin phosphorylation mediated by TESK1. The composition for inhibiting resistance to anticancer agents, according to the present invention, inhibits cancer cells from having resistance to anticancer agents by inhibiting actin remodeling occurring in accordance with the administration of anticancer agents, thereby being useful in the inhibition of resistance to anticancer agents.La présente invention concerne une composition pour inhiber la résistance à des agents anticancéreux, contenant, en tant que substance active, un inhibiteur de TESK1 ou un inhibiteur de phosphorylation de cofiline médiée par TESK1. La composition pour inhiber la résistance à des agents anticancéreux, selon la présente invention, empêche les cellules cancéreuses de présenter une résistance à des agents anticancéreux par inhibition de la survenue dun remodelage de lactine associée à ladministration dagents anticancéreux, de façon à être utile dans linhibition de la résistance à des agents anticancéreux.본 발명은 TESK1 억제제 또는 TESK1에 의해 매개되는 코필린 인산화 억제제를 유효성분으로 함유하는 항암제 내성 억제용 조성물에 관한 것으로, 본 발명에 따른 항암제 내성 억제용 조성물은 항암제의 투여에 따라 발생하는 액틴 리모델링을 억제하여, 암세포가 항암제에 대해 저항성을 가지는 것을 억제하여, 항암제 내성 억제에 유용하다.
