The present invention aims to disclose a pharmaceutical composition for regulating blood lipids (in particular, for treating hypertriglyceridemia) and a preparation method therefor. The present invention also aims to disclose the medicinal uses of the pharmaceutical composition. The red yeast and the evening primrose in the present pharmaceutical composition complement one other and generate an amplification effect, providing the effects of de-humidification, phlegm removal, blood circulation, blood stasis removal, spleen strengthening, and digestion assistance. The present pharmaceutical composition reduces the total cholesterol in blood, increases the high-density lipoprotein concentration, lowers the low-density lipoprotein concentration, and in particular, has substantial effects of lowering triglyceride and treating hypertriglyceridemia. The present invention has a logical manufacturing process that enhances the concentration of the effective component, lovastatin, in the red yeast, while maintaining the active ingredients of different medicine in the prescription, thereby fully using all medicines. The preparation of the present invention uses the concentration of lovastatin as the quality control indicator, and the preparation quality is stable and controllable.La présente invention concerne une composition pharmaceutique pour réguler les lipides dans le sang (en particulier, pour traiter lhypertriglycéridémie) et un procédé de préparation correspondant. Linvention concerne également des utilisations médicinales de la composition pharmaceutique. La levure rouge et lonagre contenus dans la composition pharmaceutique de linvention se complètent mutuellement et génèrent un effet damplification, permettant dobtenir des effets de déshumidification, délimination des mucosités, de circulation sanguine, élimination de la stase sanguine, le renforcement de la masse splénique et laide à la digestion. La composition pharmaceutique de linvention permet de réduire le chol