sGC刺激劑农业专利-农业专业知识服务系统

发明人:: RENNIE, GLEN ROBERT,瑞尼　葛兰　罗伯特,瑞尼　葛蘭　羅伯特,IYENGAR, RAJESH R.,英格　罗杰斯　R,英格　羅傑斯　R,LEE, THOMAS WAI-HO,李　维浩,李　維浩,NAKAI, TAKASHI,中井崇,MERMERIAN, ARA,莫马恩　阿尔,莫馬恩　阿爾,JIA, JAMES,贾　磊,賈　磊,IM, G-YOON JAMIE,任志胤,任志,瑞尼葛兰罗伯特,瑞尼葛蘭羅伯特,英格罗杰斯 R,英格羅傑斯 R,李维浩,李維浩,莫马恩阿尔,莫馬恩阿爾,贾磊,賈磊

摘要：: The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP), or both, or an upregulation of the NO pathway is desirable. The compounds are of Formula I:本發明係關於可溶性鳥苷酸環化酶(sGC)的刺激劑、包含其之醫藥調配物及其用途，其單獨或與一或多種其他藥劑組合用於治療多種疾病，其中一氧化氮(NO)之濃度增加或環單磷酸鳥苷(cGMP)之濃度增加或二者皆有或NO路徑上調係合意的。該等化合物具有式I：。