An integrated interface of a detector module of a Positron Emission Tomography (PET) may include a power module, a clock module, a synchronization module, and a communication module. In one embodiment, Gigabit Ethernet, 10G Ethernet, Fast Ethernet (100M), 10M Ethernet or custom speed Ethernet based solution can be used in the communication module. In the power module, the power is can be transmitted by standard PoE (Power over Ethernet) method, while the clock can be recovered from Ethernet in the clock module. In the synchronization module, in one embodiment, the synchronization can be done through a dedicated package and/or IEEE1588. The integrated interface can be implemented in other systems. For example, it can be used in a gamma camera system or gamma probe, especially a dynamic gamma camera or handheld gamma camera.