The present invention relates to a hybrid implant for the support and/or the replacement of tissue, a method for its preparation and its use. According to the invention, the hybrid implant is made of a polymeric scaffold combined with a mechanically stable template. It is particularly suitable for the disorders and pathologies where the support and/or the replacement of a tissue is necessary. The hybrid implant is particularly designed for cell colonization at a particular part of the implant or the whole implant, in order to restore the tissue functioning.