The present invention pertains to: a ligand-binding molecule, the ligand binding activity of which is reduced by cleavage of a cleavage site thereof； a production method for the ligand-binding molecule； a complex formed of the ligand-binding molecule and a ligand； a fusion protein including the ligand-binding molecule and a ligand； and a pharmaceutical composition including the ligand-binding molecule, or including a fusion protein of the ligand-binding molecule and a ligand.本發明係關於藉由在切斷位點被切斷而減弱對於配體之結合活性之配體結合分子及其製造方法、由該配體結合分子與配體形成之複合體、含有該配體結合分子與配體之融合蛋白質、含有配體結合分子或配體結合分子與配體之融合蛋白質之醫藥組合物。
