PROBLEM TO BE SOLVED: To provide a new medicine which is high in safety, has a sufficiently strong action for inhibiting the production of inflammatory cytokines such as TNF-&alpha and IL-6, and is useful as an anti-inflammatory agent or the like.SOLUTION: This agent for inhibiting the production of the inflammatory cytokines such as TNF-&alpha is characterized by containing guaiacol or a catechol nucleus-having amide or ester type derivative or chalcone derivative, and a highly unsaturated fatty acid such as docosahexaenoic acid, its glyceride or lower alkyl ester combinedly as active ingredients.COPYRIGHT: (C)2008,JPO&INPIT【課題】安全性が高く、しかもTNF-αやIL-6など炎症性サイトカインの産生抑制作用が十分に強く、抗炎症剤等として有用な新規な薬剤を提供する。【解決手段】グアヤコール又はカテコール核を持つアミドやエステル型誘導体あるいはカルコン誘導体と、ドコサヘキサエン酸等の高度不飽和脂肪酸、そのグリセリド又は低級アルキルエステルとを有効成分として併用し、TNFα等の炎症性サイトカインの産生抑制剤とする。【選択図】なし
