ASSOC. PROF. DR. IIS SOPYAN,TOIBAH BINTI ABD RAHIM
申请号：
MYPI 20084585
公开号：
MY148222A
申请日:
2008.11.14
申请国别(地区):
MY
年份:
2013
代理人:
摘要：
THIS INVENTION RELATES TO A POLYMERIC SPONGE METHOD IN PRODUCING POROUS BIPHASIC CALCIUM PHOSPHATE CERAMICS CONTAINING MAGNESIUM FOR HIGH PERFORMANCE BIOACTIVE BONE SCAFFOLD APPLICATIONS. POLYMERIC SPONGE METHOD IS ABLE TO PROVIDE A PROPER PORE SIZE DISTRIBUTION, AS OSTEOCONDUCTION REQUIRES. THIS IS CHARACTERIZED BY THE EXISTENCE OF MICRO/MESO/MACROPORES WITH ADEQUATE DEGREE OF INTERCONNECTION. CALCIUM PHOSPHATE IS AN INTERESTING MATERIAL FOR BONE IMPLANT APPLICATIONS, AS IT SHOWS BIOCOMPATIBILITY AND BIOACTIVITY TO TISSUE BONE. AMONG CALCIUM PHOSPHATE- BASED MATERIALS, BIPHASIC CALCIUM PHOSPHATE (BCP), A MIXTURE OF NON-RESORBABLE HYDROXYAPATITE (HA) AND RESORBABLE TRICALCIUM PHOSPHATE (TCP), HAS SHOWN TO POSSESS UNIQUE CHARACTERISTICS APPROPRIATE FOR BONE REPLACEMENT. DOPING OF MAGNESIUM IONS INTO BCP WILL BRING BIOLOGICAL IMPROVEMENT. MAGNESIUM ION WAS FOUND TO CAUSE THE ACCELERATION OF NUCLEATION KINETICS OF BONE MINERALS. THEREFORE, THE INCORPORATION OF MAGNESIUM IONS INTO THE CALCIUM PHOSPHATE STRUCTURE IS OF GREAT INTEREST FOR THE DEVELOPMENT OF ARTIFICIAL BONE.
