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COMPLEXES OF IL-15 AND IL-15RALPHA AND USES THEREOF
专利权人:
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; INC.;MARINE POLYMER TECHNOLOGIES, INC.;MARINE POLYMER TECHNOLOGIES
发明人:
PAVLAKIS, GEORGE N
申请号:
NZ59933808
公开号:
NZ599338A
申请日:
2008.06.27
申请国别(地区):
NZ
年份:
2013
代理人:
摘要:
NZ 599338 Disclosed is an isolated cell that recombinantly expresses a mammalian interleukin (IL-15); and a mammalian interleukin-15 receptor alpha (IL-15Ra), a soluble form of a mammalian IL-15Ra, a polypeptide comprising a mammalian IL-15Ra and a first heterologous molecule, or a polypeptide comprising a soluble form of a mammalian IL-15Ra and a second heterologous molecule, wherein the cell expresses at least 0.15 pg of mammalian IL-15 per day when cultured in serum-free media, and wherein the cell is not a human totipotent stem cell.
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