Prosthesis (1a) for repair of an inguinal hernia, intended to be implanted laparoscopically, comprising openwork fabric of biocompatible material, comprising a first surface, called parietal surface, intended to be placed facing biological tissues of the inguinal region, and a second surface, opposite the first surface, called peritoneal surface, intended to be placed facing the peritoneum, the peritoneal surface comprising, on a portion of the surface thereof, a first zone (6), provided with a non-stick coating, the parietal surface comprising, on a portion of the surface thereof, a second zone (7) provided with a non-stick coating.