ALLEGRETTI, MARCELLO,MORICONI, ALESSIO,ARAMINI, ANDREA,CESTA, MARIA CANDIDA,BECCARI, ANDREA,BERTINI, RICCARDO
申请号：
CA2629935
公开号：
CA2629935C
申请日:
2006.11.24
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention relates to selected (R)-arylalkylamino derivatives offormula (I), in which R, R1 and Ar are as defined in the claims. Thesecompounds show a surprising potent inhibitory effect on C5a induced human PMNchemotaxis. The compounds of the invention absolutely lack of CXCL8 inhibitoryactivity. Said compounds are useful in the treatment of pathologies dependingon the chemotactic activation of neutrophils and monocytes induced by thefraction C5a of the complement. In particular, the compounds of the inventionare useful in the treatment of sepsis, psoriasis, rheumatoid arthritis,ulcerative colitis, acute respiratory distress syndrome, idiopathic fibrosis,glomerulonephritis and in the prevention and treatment of injury caused byischemia and reperfusion.
