CYTOTOXICITY-INDUCING THERAPEUTIC AGENT

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专利权人:

CHUGAI SEIYAKU KABUSHIKI KAISHA

发明人:

NEZU, JUNICHI,NARITA, ATSUSHI,ISHIGURO, TAKAHIRO,SAKURAI, MIKA,SHIRAIWA, HIROTAKE,HIRONIWA, NAOKA,IGAWA, TOMOYUKI,KAWAI, YUMIKO

申请号：

SG11201701119R

公开号：

SG11201701119RA

申请日:

2015.09.25

申请国别(地区):

SG

年份:

2017

代理人:

摘要：

Novel multispecific antigen-binding molecules maintaining excellent cellular cytotoxicity and high stability, which comprise a domain that contains an antibody variable region having glypican 3-binding activity and a domain that contains an antibody variable region having T-cell receptor complex-binding activity, were discovered. Since the molecules of the present invention show a strong cytotoxicity against cells and tissues expressing glypican 3, it is possible to produce novel pharmaceutical compositions for treating or preventing various cancers.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/