A system for monitoring the state of health of a patient suffering from respiratory disease including a portable medical device, the device including: a) a flow measurement device performing a spirometry measurement, and b) a reflecting photometric sensor performing an oxygen measurement or a measurement of blood oxygen saturation and heart rate. The system includes storage and comparison units in which a personalised plan of action for the patient is stored against which the spirometry and/or oxygen measurement data found are compared, displaying the result of such comparison on the display of a device connected to the internet so as to define the patient's state of health and identify exacerbation of the disease on the basis of data obtained from both such spirometry and oxygen measurements. A method for monitoring the health of a patient suffering from respiratory disease implemented through the system indicated above is also claimed.