Parenterálisan beadható azol gyógyszerkészítmények azol-vegyületekre érzékeny betegségek kezelésében való alkalmazásra, továbbá eljárások ezek elõállítására
Benigno C. Valdez;Jeffrey Tarrand;Borje S. Andersson
发明人:
ANDERSSON, Borje, S.,TARRAND, Jeffrey,VALDEZ, Benigno, C.
申请号：
HUE11849408
公开号：
HUE028667T2
申请日:
2011.12.16
申请国别(地区):
HU
年份:
2016
代理人:
摘要：
A parenteral azole composition comprises a first solvent, made of benzyl alcohol and/or an acidified alcohol such as ethanol, and a lipophilic component such as PEG400, and the azole, or triazole, such as itraconazole or posaconazole dissolved in this first composite solvent vehicle that is essentially free of surfactants, particularly non-ionic surfactants, and has low levels of water, preferably less than 5% water. The composition may be further diluted with an infusion fluid, such as normal saline or 5% or 10% dextrose in water, before infusion into an immunocompromized mammal, preferably a human. The composition is useful for the treatment and suppression of infections caused by microbes such as yeast and molds that are sensitive to azoles, but it may be extended to dissolve other pharmaceutically active agents that can be used to treat other types of infectious diseases or other ailments, such as malignant and autoimmune diseases.
