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Detection of polymorphisms in monkey CYP2C and CYP2D genes and use thereof
专利权人:
株式会社新日本科学
发明人:
宇野 泰広,上原 正太郎,松下 聡紀,小原 栄,鵜藤 雅裕
申请号:
JP2013191104
公开号:
JP6342634B2
申请日:
2013.09.13
申请国别(地区):
JP
年份:
2018
代理人:
摘要:
PROBLEM TO BE SOLVED: To provide a method for selecting a suitable monkey as a model animal by detecting presence or absence of polymorphism which is identified as the polymorphism altering expression and/or function of a drug-metabolizing enzyme in a gene encoding CYP2C43, CYP2C75, CYP2D17, and CYP2D44 of a monkey.SOLUTION: The invention provides a method for selecting a model animal used for examining pharmacokinetics, drug efficacy and/or safety about pharmaceutical candidate compounds for humans, comprising a step of detecting polymorphism of a gene encoding a drug-metabolizing enzyme belonging to CYP2C and CYP2D subfamily in a monkey individual, and a step of evaluating whether the polymorphism alters the expression and/or function of the drug-metabolizing enzyme.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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