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III. Nitrogen-containing trichloride compounds and their applications in medicine
专利权人:
SUNSHINE LAKE PHARMA CO.; LTD.
发明人:
ZHANG, YINGJUN,CAO, SHENGTIAN,PAN, SHENGQIANG,XIONG, SHAOHUI,WU, JUNWEN,YANG, XINYE,WANG, XIAOJUN
申请号:
ARP170102212
公开号:
AR109295A1
申请日:
2017.08.04
申请国别(地区):
AR
年份:
2018
代理人:
摘要:
Tricyclic compounds containing nitrogen as XR modulatorsOr a stereoisomerGeometric isomersTaurus,A N-oxide,A hydrateA month agoA MetabolismAn acceptable salt or an acceptable salt.Conditions for the treatment of diseases and/or mediation through FXR using compounds. In addition, a pharmaceutical component containing the compounds currently described, as well as a method of treating diseases and/or conditions mediated by FXR, including the management of compounds or their pharmaceutical components. Claim 1: A compound that submits formula (1),Or steroidsGeometric isomersTaurus,A N-oxide,A hydrateA month agoA MetabolismAn acceptable salt or an acceptable salt.Where T is - NH,- It's...- Yes.- C(= O) - O-CH83222-;Each X and Y is a separate link.- It's...- S(= O) 8348;- 739- CR 696; - R7611A - O - C (= O) -,O-x-y-es-chr RZ 68-chr75030-o-cr6966 = Cr-7611-;Each r739 is a separate hydrogen.Deuterium,SomeoneAminopropylHalide.Bicycle.cumeneArilo,1. Arilo Halo replacement or Arilalquilo;Each R6966 and R7611A is a separate hydrogen.Deuterium,F,LL,Uh...I,HydrofluorocarbonsAminoNitro,CyanogenSomeoneHalide.Hydrogen oxidationAminopropylAlcoxi,Rental.Alquenilo,Blue Nile StateBicycle.cumeneArilo,1. Arilo Halo replacement or Arilalquilo;O R6966 and R7611A, together with the associated carbon atoms,Independent, selective formation of rings or heteromorphic rings.Where ring A and ring A are independent and optional substitutes selected from F.LL,Uh...I,HydrofluorocarbonsAminoNitro,CyanogenMethylEthyl group.Isopropyl and trifluoride acyl;Each r688e and R75030 is a separate hydrogen.Deuterium,F,LL,Uh...I,HydrofluorocarbonsAminoNitro,CyanogenMethylEthyl group.3. Isopropyl or trifluorination;O R6888y and R7503;Plus the coal atoms they connect togetherForm a ring or a special ring.Among them, ring A ring and ring non-ring ring rings are independent and optional, and are replaced by selected F.LL,Uh...I,HydrofluorocarbonsAminoNitro,CyanogenMethylEthyl group.Isopropyl and trifluoride acyl;Each
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