It is possible to inhibit the production of volatile sulfur compounds by oral bacteria and caries resistance and infectious pathogenic properties without endocarditis, safe new lactic acid bacteria and oral diseases which was used in the oral cavity and prevention of discomfort, provision of an improved and / or therapeutic agent. Lactobacillus Kurisupatasu (Lactobacillus crispatus), Lactobacillus fermentum (Lactobacillus fermentum), it is selected from Lactobacillus gasseri (Lactobacillus gasseri) and Streptococcus mitis (Streptococcus mitis), and all of the following (1) to (6) prevention and / or therapeutic agent for the nature oral disease with one or more lactic acid bacteria as an active ingredient with a. (1) volatile sulfur compounds (VSC) does not have the production capacity (2) water-insoluble glucan producing ability does not have a (3) having adhesion to the tooth surface and / or cells in the mouth (4) bad breath-causing bacteria and / or have a growth inhibitory effect on periodontal pathogenic bacteria (5) does not have an inflammatory of infectious endocarditis (6) does not have a cariogenic口腔細菌による揮発性硫黄化合物の産生を抑制することができ、且つう蝕性及び感染性心内膜炎の起炎性がなく、口腔内で安全な新規乳酸菌株及びこれを用いた口腔内疾患や不快症状の予防、改善及び/又は治療剤の提供。ラクトバチルス・クリスパータス(Lactobacilluscrispatus)、ラクトバチルス・ファーメンタム(Lactobacillusfermentum)、ラクトバチルス・ガッセリ(Lactobacillusgasseri)及びストレプトコッカス・ミティス(Streptococcusmitis)から選ばれ、且つ下記(1)~(6)の全ての性質を有する1種又は2種以上の乳酸菌を有効成分とする口腔内疾患の予防及び/又は治療剤。(1)揮発性硫黄化合物(VSC)産生能を有しない(2)非水溶性グルカン産生能を有しない(3)歯面及び/又は口腔内細胞への接着性を有する(4)口臭原因菌及び/又は歯周病原性細菌に対する増殖阻害作用を有する(5)感染性心内膜炎の起炎性を有しない(6)う蝕性を有しない
