A new Poinsettia plant named ‘Ruby Frost,’ particularly distinguished by the variegated red and white bract color, medium sized inflorescences held well above the foliage canopy, medium to deep green foliage that are ovate to oak-shaped bracts and leaves with pointed lobes, medium sized, well-branched and mounding plant habit, mid-season flowering response, and good keeping quality of foliage and bracts.