Vlahov, Iontcho Radoslavov,Leamon, Christopher Paul
申请号：
AU2013204293
公开号：
AU2013204293A1
申请日:
2013.04.12
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
#$%^&*AU2013204293A120130509.pdf#####MULTI-DRUG LIGAND CONJUGATES ABSTRACT 1500 Contls (a) 1260-TumorVolume &o4 (mar) 750500 as . c) 260(b 0 0 10 20 30 40 50 60 70 80 PTI (Days) Described herein are compounds, pharmaceutical compositions and methods for treating pathogenic cell populations in a patient. The compounds described herein include conjugates of a plurality of cytotoxic drugs and vitamin receptor binding ligands. The plurality of drugs may be the same or different. Similarly, the vitamin receptor binding ligands may be the same or different. The conjugates also include a linker that is formed from one or more spacer liners, hetematom linkers, and releasable linkers.
