PROBLEM TO BE SOLVED: To provide a TNF-α inhibitor which is inexpensive and capable of being administered orally.SOLUTION: The invention provides a Tnf-α production inhibitor containing one or more kinds of components selected from the group consisting of a component of rehmannia root, a component of cornus fruit, a component of dioscorea rhizome, a component of alisma rhizome, a component of poria sclerotium, a component of aconite tuber, a component of achyranthes root, a component of moutan bark, a component of cinnamomi cortex, and a component of plantago seed.COPYRIGHT: (C)2016,JPO&INPIT【課題】安価かつ経口投与可能なTNF-α阻害剤を提供すること。【解決手段】ジオウの含有成分、サンシュユの含有成分、サンヤクの含有成分、タクシャの含有成分、ブクリョウの含有成分、ボタンピの含有成分、ケイヒの含有成分、ブシの含有成分、ゴシツの含有成分およびシャゼンシの含有成分からなる群より選択される一種または二種以上の成分を含有するTNF-α産生抑制剤。【選択図】なし