MOORE STEPHEN JAMES,NGUYEN MARGARET THY LUU,HOSTETTER DANIEL R,VASILJEVA OLGA,SAGERT JASON GARY,TERRETT JONATHAN ALEXANDER,WEST JAMES WILLIAM
申请号：
IN201727029190
公开号：
IN201727029190A
申请日:
2017.08.17
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
The invention relates generally to polypeptides that include at least a first cleavable moiety (CM1) that is a substrate for at least one matrix metalloprotease (MMP) and at least a second cleavable moiety (CM2) that is a substrate for at least one serine protease (SP) to activatable antibodies and other larger molecules that include these polypeptides that include at least a CM1 that is a substrate for at least one MMP protease and at least a CM2 that is a substrate for at least one SP protease and to methods of making and using these polypeptides that include at least a CM1 that is a substrate for at least one MMP protease and at least a CM2 that is a substrate for at least one SP protease in a variety of therapeutic diagnostic and prophylactic indications.
