THUDIUM KENT B,KORMAN ALAN J,YAMANAKA MARK,SELBY MARK,ZENS KYRA D,LEBLANC HEIDI
申请号：
NZ60278009
公开号：
NZ602780A
申请日:
2009.08.11
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
602780 Disclosed is an isolated monoclonal antibody, or an antigen-binding portion thereof, which binds human LAG-3, wherein the antibody comprises heavy and light chain variable region sequences having at least 80% amino acid sequence identity to SEQ ID NOs: 40 and 46, respectively. Further disclosed is an isolated monoclonal antibody, or an antigen-binding portion thereof, which binds human LAG-3, wherein the antibody comprises heavy chain variable region CDR1, CDR2, and CDR3 sequences as set forth in SEQ ID NOs: 4, 10, and 16, respectively, and light chain variable region CDR1, CDR2, and CDR3 sequences as set forth in SEQ ID NOs: 22, 28, and 34, respectively. >40QVQLQQWGAGLLKPSETLSLTCAVYGGSFSGYYWSWIRQPPGKGLEWIGEINHRGNTNCNPSLKSRVTISGDTSKKQFALKLNSVTAADTAVYYCARGYDILTGYYEDSWGPGTLVTVSS >46EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYNASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPLTFGGGTKVEIK
