John Chen,Johan Fransson,Natalie Fursov,Damon Hamel,Thomas Malia,Galina Obmolova,Tatiana Ort,Michael Rycyzyn,Michael Scully,Raymond Sweet,Alexey Teplyakov,John Wheeler,Juan Carlos Almagro
申请号：
US14790144
公开号：
US09683046B2
申请日:
2015.07.02
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Human antibodies immunospecific for human CD27 are capable of blocking CD27 binding to its ligand CD70 and neutralizing bioactivity of CD27 including, but not limited to, CD27 intracellular signaling, T-cell proliferation and activation, B-cell proliferation and differentiation, plasmablast formation and alleviation of antibody responses, stimulation of tumor cells by CD70, and the production of soluble mediators from T and B-cells. The antibodies are useful in diagnosing or treating CD27 activity associated diseases and conditions.
