The present invention provides a variant and fusion of fibroblast growth factor 19 (FGF19), a variant and fusion of fibroblast growth factor 21 (FGF21), having one or more activities such as bile acid homeostasis modulating activity, FGF19 And / or FGF21 fusions, and variants or fusions of FGF19 and / or FGF21 protein and peptide sequences (and peptidomimetics), and methods and uses in the treatment of bile acid disorders and other disorders. [Selection] Figure 1本発明は、胆汁酸ホメオスタシス調整活性などの1種以上の活性を有する、線維芽細胞増殖因子19(FGF19)の変種及び融合体、線維芽細胞増殖因子21(FGF21)の変種及び融合体、FGF19及び／又はFGF21の融合体、並びにFGF19及び／又はFGF21のタンパク質配列及びペプチド配列(及びペプチド模倣体)の変種又は融合体、並びに胆汁酸障害及び他の障害の治療における方法及び使用に関する。【選択図】図１
