PEREZ GARCIA, JUAN BAUTISTA,CARRERA CARRERA, FRANCESC,GARCIA MARTIN, DIGNA JOSE,BOIX BERNARDINI, MARIA CARMEN
申请号：
PE0015992011
公开号：
PE01712012A1
申请日:
2010.03.11
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Referring to a Crystalline Salt of formula (i) addition of an Amine which has one or more hydroxyl groups and \/ or with a carboxylic acid derivative aminonicotinico, where ra, RB, RC and Rd are h, halogen, c1-c4 alkyl, among others.Preferred compounds are: Meglumine Salt acid 2 - {[3 - ethoxy - 3 - (trifluoromethoxy) - 1,1 - biphenyl - 4-yl] amino} Nicotinic acid tromethamine Salt of 2 - {[(3.5 - difluoro - 2 - methyl - 1,1 - biphenyl - 4-yl] amino} Nicotinic acid arginine Salt of L - [2 - (3,5-difluoro-3 - methoxy - 1,1 - biphenyl - 4-yl) amino] nicotinic Or, among others. Also referred to a Pharmaceutical composition.This Salt has Inhibitory activity of dehydrogenase (dihidroorato DHODH) and is useful in the treatment of rheumatoid arthritis, psoriatic arthritis, multiple sclerosis, among othersREFERIDA A UNA SAL DE ADICION CRISTALINA DE FORMULA (I) DE UNA AMINA QUE TIENE UNO O MAS GRUPOS HIDROXILO Y/O CARBOXILICOS CON UN DERIVADO DE ACIDO AMINONICOTINICO, DONDE Ra, Rb, Rc Y Rd SON H, HALOGENO, ALQUILO C1-C4, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: SAL DE MEGLUMINA DE ACIDO 2-{[3-ETOXI-3-(TRIFLUOROMETOXI)-1,1-BIFENIL-4-IL]AMINO}NICOTINICO, SAL DE TROMETAMINA DE ACIDO 2-{[(3,5-DIFLUORO-2-METIL-1,1-BIFENIL-4-IL]AMINO}NICOTINICO, SAL DE L-ARGININA DE ACIDO 2-[(3,5-DIFLUORO-3-METOXI-1,1-BIFENIL-4-IL)AMINO]NICOTINICO, ENTRE OTRAS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHA SAL TIENE ACTIVIDAD INHIBIDORA DE DIHIDROORATO DE DESHIDROGENASA (DHODH) Y ES UTIL EN EL TRATAMIENTO DE ARTRITIS REUMATOIDE, ARTRITIS PSORIASICA, ESCLEROSIS MULTIPLE, ENTRE OTRAS
