A medical system (10) and method monitor a patient. Patient data for the patient received. The patient data includes vital sign measurements and laboratory results. A vital signs instability index (VIX) regarding a physiological condition of the patient is calculated from the received vital sign measurements. A laboratory instability index (LIX) regarding the physiological condition is calculated from the received laboratory results. The VIX and the LIX are integrated into an indicator of patient deterioration.