FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;ALBERT-LUDWIGS-UNIVERSITAT FREIBURG
发明人:
GRUNWALD, INGO,RICHTER, KATHARINA,MIERNIK, ARKADIUSZ,SCHOENTHALER, MARTIN
申请号：
CA2910201
公开号：
CA2910201A1
申请日:
2013.08.22
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Described primarily are gel-forming systems consisting of or comprising a composition (A), comprising one or more cationically crosslinkable polymers, and a composition (B), comprising one or more crosslinking agents for crosslinking the cationically crosslinkable polymer(s), for use in a method for removing urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, from a region of the urinary tract, more particularly a kidney, that contains urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, that are to be removed, comprising the following steps: (i) providing the compositions (A) and (B), (ii) introducing the compositions (A) and (B) into a region of the urinary tract, more particularly the kidney, that contains urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, that are to be removed, under conditions enabling crosslinking of the cationically crosslinkable polymer(s) on contact between compositions (A) and (B), to form a crosslinked gel that partly or fully surrounds the urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, that are to be removed, (iii) removing the crosslinked gel together with the urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, that are surrounded with it from the urinary tract, more particularly the kidney.
