Buckley, Dennis,Bradner, James,Remillard, David Ian
申请号：
AU2017281903
公开号：
AU2017281903A1
申请日:
2017.06.23
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
The present application provides bifunctional compounds of Formula (I): or an enantiomer, diastereomer, or stereoisomer thereof, or pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, which act as protein degradation inducing moieties for bromodomain-containing protein 9 (BRD9). The present application also provides methods for the targeted degradation of BRD9 through the use of the bifunctional compounds that link a ubiquitin ligase-binding moiety to a ligand that is capable of binding to BRD9 which can be utilized in the treatment of disorders modulated by BRD9.
