In a vertebral body replacement implant having a bottom locating part for positioning against a lower vertebral body and having a top locating part for positioning against an upper vertebral body, wherein both locating parts are telescopically displaceable relative to one another in the manner of a piston-cylinder unit, having a sealed hydraulic chamber formed by the locating parts, having a charging opening leading into the hydraulic chamber for a hydraulic medium, which upon entering the hydraulic chamber pushes the two locating parts apart from one another, and having a locking device, which may be activated by means of an instrument and upon activation fixes the two locating parts non-displaceably relative to one another, in order to facilitate the handling of the vertebral body replacement implant it is proposed that the locking device is disposed on the vertebral body replacement implant in the region of the charging opening. An instrument for handling the vertebral body replacement implant is also proposed.
