The present invention relates to the antipsoriatic emulsion composition, especially in the form of a cream, comprising an effective therapeutic dose of cefazolin, the ingredients of the oil phase and the ingredients of the water phase, characterized by that (i) the ingredients of the oil phase include: - liquid paraffin or white petrolatum, - polyoxyethylene stearyl ether (21), and - cetostearyl alcohol； (ii) the ingredients of the oil phase include a buffer solution to maintain the pH value of the initial composition from 5 to 9, preferably in the range 6 - 8, (iii) optionally, comprising an additional amphiphilic nonionic emulsifier, and other soluble/water miscible excipients, wherein water content accounts for 50 to 80% by weight of the composition.
