MÉTHODE DE CRIBLAGE DE SUBSTANCES QUI AFFECTENT LA FORMATION, LA STRUCTURE OU LA FONCTION DE VAISSEAUX SANGUINS HUMAINS ET MÉTHODE DE PRODUCTION DE VAISSEAUX SANGUINS HUMAINS
A method for screening substances that promote or suppress the formation of human blood vessels, or substances that normalize the structure or function of human blood vessels, the method including: (1) a step for cutting part of the skin of a non-human immunodeficient animal and exposing subcutaneous tissue or a muscle layer； (2) a step for placing human tissue on the exposed subcutaneous tissue or muscle layer； (3) a step for sealing the placed human tissue so that the placed human tissue is not in contact with the air； (4) a step for grafting the human tissue to the non-human immunodeficient animal； (5) a step for administering a substance to be tested into the non-human immunodeficient animal to which the human tissue was grafted as obtained in steps (1) to (4)； (6) a step for observing the formation or structure of human blood vessels in the human blood tissue, and/or evaluating the function of the human blood vessels； and (7) a step for comparing with human blood vessels in a non-human immunodeficient animal to which human tissue was grafted and in which no substance to be tested was administered, and selecting either a substance to be tested that promotes or suppresses the formation of human blood vessels, or a substance to be tested that normalizes the structure or function of the human blood vessels.L'invention concerne une méthode de criblage de substances qui favorisent ou suppriment la formation de vaisseaux sanguins humains ou de substances qui normalisent la structure ou la fonction de vaisseaux sanguins humains, la méthode comprenant : (1) la découpe d'une partie de la peau d'un animal non humain immunodéprimé et l'exposition d'un tissu sous-cutané ou d'une couche musculaire ； (2) le placement d'un tissu humain sur le tissu sous-cutané exposé ou la couche musculaire exposée ； (3) le scellement du tissu humain placé de telle sorte que le tissu humain placé ne soit pas en contact avec l'air ； (4) la greffe du tissu humain sur l'animal non humain immunodé
