#$%^&*AU2010201263B220121220.pdf#####ABSTRACT A method of treating a transthyretin amyloid disease, the method comprising orally administering 250 mg of 2',4'-difluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid twice per 5 day to a subject diagnosed as having a transthyretin amyloid disease.