CHANG, MARGARET DAH TSYR,张大慈,張大慈,FANG, SHUN LUNG,方韶珑,方韶瓏,CHOU, WEI I,周维宜,周維宜,LIN, SHU CHUAN,林淑娟,林淑娟
申请号：
TW100116711
公开号：
TW201207111A
申请日:
2011.05.12
申请国别(地区):
TW
年份:
2012
代理人:
摘要：
The present invention provides a cell penetrating peptide which has following sequence: NYBX1BX2BNQX3. The present invention further provides a method of intracellular delivery comprising: (a) providing a cell penetrating peptide of the present invention, and (b) incubating the cell penetrating peptide with targeted cells. The present invention also provides a complex comprising the cell penetrating peptide of the present invention and a cargo selected from the group consisting of therapeutic agents, diagnostic probes, peptides, nucleic acids, antisense oligonucleotides, proteins, nanoparticles, liposomes, small molecules and labeled materials.本發明提供一種細胞穿透胜肽,其具有下列胺基酸序列:NYBX1BX2BNQX3。本發明進一步提供一種胞內輸送之方法,包括:(a)提供一本發明之細胞穿透胜肽,及(b)將該細胞穿透胜肽與目標細胞進行培養。本發明亦提供一種複合物,其包含本發明之細胞穿透胜肽及一種選自由治療劑、診斷探針、胜肽、核苷酸、反義寡核酸、蛋白質、奈米粒子、微脂體、小分子及標記物質所組成之群組的物質。
