SZULC, ZDZISLAW, M.,BIELAWSKA, ALICJA,OBEID, LINA, M.,HANNUN, YUSUF, A.,NORRIS, JAMES,XIANG, LIU
申请号：
EP09837076
公开号：
EP2384118A4
申请日:
2009.12.28
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
The presently disclosed subject matter provides compounds of the formula: (1) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, and R8 are as defined herein. Also disclosed are methods for making the compounds of the formula as set forth hereinabove, their use in inhibiting sphingosine kinase, and their use in the treatment and/or prevention of diseases and/or conditions associated with undesirable ceramidase or sphingosine kinase activity, including, but not limit cancer, cancer metastasis, atherosclerosis, stenosis, inflammation, immunological disorders, asthma, atopic dermatitis, wound healing, and other proliferative diseases.
