Mark J. Graham;Adam Mullick;Richard Lee;Rosanne M. Crooke;Thomas A. Bell, III;Kenneth W. Dobie
发明人:
Adam Mullick,Rosanne M. Crooke,Mark J. Graham,Kenneth W. Dobie,Thomas A. Bell, III,Richard Lee
申请号：
US14114187
公开号：
US20140128453A1
申请日:
2012.04.27
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Provided herein are methods, compounds, and compositions for reducing expression of ApoCIII mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for increasing HDL levels and/or improving the ratio of TG to HDL and reducing plasma lipids and plasma glucose in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of cardiovascular disease or metabolic disorder, or a symptom thereof.
