John Robert Pollard,Philip Michael Reaper,Mohammed Asmal
申请号：
US13857658
公开号：
US20140044802A1
申请日:
2013.04.05
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to compounds useful as inhibitors of ATR protein kinase and combination therapies thereof. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention； methods of treating of various diseases, disorders, and conditions using the compounds of this invention； processes for preparing the compounds of this invention； intermediates for the preparation of the compounds of this invention； and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena； the study of intracellular signal transduction pathways mediated by such kinases； and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I:wherein the variables are as defined herein.
