DEWDNEY, NOLAN JAMES,GABRIEL, TOBIAS,KONDRU, RAMA K.,LOU, YAN,SOTH, MICHAEL
申请号：
CA2701275
公开号：
CA2701275C
申请日:
2008.10.14
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Pyridine and pyrimidine compounds according to formula (I)wherein R1, R2, R3, R4, R5, X~ and A are as described herein which inhibitBtk. The compounds disclosed herein are useful to modulate the activity ofBtk and treat diseases associated with excessive Btk activity. The compoundsare further useful to treat inflammatory and auto immune diseases associatedwith aberrant B-cell proliferation such as rheumatoid arthritis. Alsodisclosedare compositions containing compounds of formula (I) and at least one carrier,diluent or excipient.
