Relating to compounds of formula (i) where a is imidazo [1,2-b] pyridazine hydrochloride, 1,2,4 triazolo [1,5-a] [b] pyridazine hydrochloride, among others phenyl substituted r1 R2 is feline, piridilo, where such groups are replaced by Halo, Hydroxy, among others.Preferred compounds are: 2 - (4-fluorophenyl) - N - [4 - (2 - {[2 - methoxy - 3 - ((4 - ilcarbonil) phenyl] amino} [1,2,4] triazolo [1,5-a] pyridazin-3 (IL - 6) phenyl] acetamide 2 - (4-fluorophenyl) - N - [4 - (2 - ((4 - (2 - hidroxipropan - 2 - il) - 2-methoxyphenyl] amino} [1,2,4] triazolo [1,5-a] pyridazin-3 (IL - 6) phenyl] acetamide among others.These compounds inhibit the kinase MPS - 1, being useful in the Treatment or prophylaxis of diseases related to Growth, Survival and \/ or uncontrolled Cell Proliferation, cellular immune response inadequate or inappropriate Cellular inflammatory responseReferida a compuestos de formula (I) donde A es imidazo[1,2-b]piridazina, [1,2,4]triazolo[1,5-b]piridazina, entre otros R1 es fenilo sustituido R2 es felino, piridilo, donde dichos grupos son sustituido por halo, hidroxi, entre otros. Son compuestos preferidos: 2-(4-fluorofenil)-N-[4-(2-{[2-metoxi-4-(morfolin-4-ilcarbonil)fenil]amino} [1,2,4]triazolo[1,5-b]piridazin-6-il)fenil]acetamida 2-(4-fluorofenil)-N-[4-(2-{[4-(2-hidroxipropan-2-il)-2-metoxifenil]amino} [1,2,4]triazolo[1,5-b]piridazin-6-il)fenil]acetamida entre otros. Dichos compuestos inhiben la Mps-1 quinasa, siendo utiles en el tratamiento o profilaxis de enfermedades relacionadas con un crecimiento, una proliferacion y/o supervivencia celular descontrolada, con una respuesta inmune celular inapropiada o una respuesta inflamatoria celular inapropiada
