VAN DELFT FLORIS LOUIS,VAN GEEL REMON,WIJDEVEN MARIA ANTONIA
申请号：
IN3397/DELNP/2015
公开号：
IN2015DN03397A
申请日:
2015.04.22
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
The present invention relates to an antibody comprising a GlcNAc- S(A)x substituent, wherein S(A)xis a sugar derivative comprising x functional groups A wherein A is independently selected from the group consisting of an azido group , a keto group and an alkynyl group and x is 1 , 2 , 3 or 4, wherein said GlcNAc- S(A)x substituent is bonded to the antibody via CI of the N- acetylglucosamine of said GlcNAc S(A)x substituent, and wherein said N- acetylglucosamine is optionally fucosylated. The invention also relates to an antibody- conjugate, in particular to an antibody- conjugate according to the Formula (20) or (20b), wherein AB is an antibody, S is a sugar or a sugar derivative , D is a molecule of interest, and wherein said N- acetylglucosamine is optionally fucosylated (b is 0 or 1). The invention further relates to a process for the preparation of a modified antibody, to a process for the preparation of an antibody- conjugate and to said antibody- conjugate, for use as a medicament. In addition the invention relates to a kit of parts comprising an azide modified antibody and a linker- conjugate , wherein said linker- conjugate comprises a (hetero)cycloalkynyl group and one or more molecules of interest.
